ENZYME INHIBITION BY STEROID ANAESTHETIC AGENTS DERIVED FROM PROGESTERONE
نویسندگان
چکیده
منابع مشابه
Reversible inhibition of natural killer cell activity by volatile anaesthetic agents in vitro.
NK cell cytotoxicity against the erythroleukaemia cell line K562 was studied, during and after the in vitro exposure to clinically-used concentrations of the general anaesthetic agents nitrous oxide, halothane and enflurane. Each of these agents produced a dose-dependent reduction in cytotoxicity. At approximately equipotent doses nitrous oxide produced less suppression than either halothane or...
متن کاملInhibition of phagocytosis and killing of bacteria by anaesthetic agents in vitro.
Polymorphonuclear leucocytes (PMNL) are an essential contribution to protection from bacterial infection. We have examined the effects of thiopentone, etomidate, ketamine and flunitrazepam on phagocytosis and killing of Staphylococcus aureus and Escherichia coli by PMNL in vitro with fluorescence microscopy. All anaesthetic agents significantly inhibited both phagocytosis and bactericidal activ...
متن کاملInhibition, by anaesthetic agents, of human leucocyte locomotion towards chemical attractants.
The effects of local, i.v. and volatile anaesthetic agents on locomotion of human blood leucocytes were studied in vitro. Blood neutrohpils and monocytes and PHA-activated lymphocytes were allowed to migrate in filters towards standard chemotactic agents and the effect of adding anaesthetic agents to the system was measured. The results showed that locomotion of all cell types was depressed rev...
متن کاملClinical studies of induction agents. XXXIX: CT1341, a new steroid anaesthetic.
CT1341 is a new intravenous anaesthetic which appears to have overcome the disadvantages of the earlier steroid. The formulation is a mixture of two closely related steroids with Cremophor EL and the optimum dose for induction is 50-60 (J/kg though much larger doses can be given without serious side effects. As the dose is increased the incidence of muscle movements, respiratory depression and ...
متن کاملAdverse reactions to anaesthetic agents.
Sir,—Even though some small changes in heart rate were shown to be statistically significant, no clinical significance was attached to such changes. The study was primarily done to assess the overall need of anticholinergic premedication in patients undergoing minor surgery and as such drugs were not administered on a weight basis. However, Dr Gilmour's comment has aroused our interest in this ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1985
ISSN: 0007-0912
DOI: 10.1093/bja/57.5.512